Harold, search on "Scheimpflug principle".
The trick is to get the subject plane, lens plane, and sensor plane to all intersect in a single line. If you can do that, then everything will be in focus.
Tilting the sensor plane will keep you in the sweet center of the lens field but will stretch & keystone the image compared to the non-tilted version.
Tilting the lens plane will move the sensor off-center in the lens field but will retain the original geometry (barring lens distortions). It can also offer a wider range of adjustment, especially at higher magnifications where the lens is relatively much closer to the subject. You can see in this example that the same subject tilt is handled with much less lens tilt (left) than sensor tilt (right)
If you're pushing the envelope of the lens then the best solution might involve tilts at both ends.
Craig, in #2 was the problem that you didn't have enough tilt range to accomplish the focus you wanted?
--Rik