Liothyronine
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Olympusman
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rjlittlefield
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These are beautiful images!
I'm curious about the process. I see on medicinenet.com that liothyronine is commonly prescribed as 5, 25, and 50 mcg tablets, or injection at 10 mcg/ml. Perhaps this has been asked before, but when the active ingredient is present at such low concentrations, how do you make sure that the crystals are from that versus some other soluble component?
--Rik
I'm curious about the process. I see on medicinenet.com that liothyronine is commonly prescribed as 5, 25, and 50 mcg tablets, or injection at 10 mcg/ml. Perhaps this has been asked before, but when the active ingredient is present at such low concentrations, how do you make sure that the crystals are from that versus some other soluble component?
--Rik
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Olympusman
- Posts: 5166
- Joined: Sun Jan 15, 2012 12:31 pm
Liothyronine
Rik,
I don't have any idea which chemical is producing which crystal formations. I simply obtain these medications from our own stock of medicines or get them from friends (which is the case with this pharmaceutical). The images you see are whatever the drug produces from the mix of active and inactive ingredients.
My process is to dissolve the pill or capsule contents in hot tap water (not boiling water).
I then filter it through facial tissue to remove most particles. (From my experience, if particles remain, the crystals will form around the particles during dehydration).
Then I centrifuge the solution. Even if the solution appears clear, I still have found a pellet of fine particular matter in the centrifuge vial.
Then I place three slides on a black piece of paper on a windowsill and put three separate drops on each slide to dehydrate. This technique gives me nine samples to examine.
I used to dehydrate the solutions by putting an aluminum plate on a coffee cup warmer and putting the slides on that, but I found that forced dehydration didn't give me very good results. I assume it didn't give the molecules of the different component chemicals enough time to find each other.
Mike
I don't have any idea which chemical is producing which crystal formations. I simply obtain these medications from our own stock of medicines or get them from friends (which is the case with this pharmaceutical). The images you see are whatever the drug produces from the mix of active and inactive ingredients.
My process is to dissolve the pill or capsule contents in hot tap water (not boiling water).
I then filter it through facial tissue to remove most particles. (From my experience, if particles remain, the crystals will form around the particles during dehydration).
Then I centrifuge the solution. Even if the solution appears clear, I still have found a pellet of fine particular matter in the centrifuge vial.
Then I place three slides on a black piece of paper on a windowsill and put three separate drops on each slide to dehydrate. This technique gives me nine samples to examine.
I used to dehydrate the solutions by putting an aluminum plate on a coffee cup warmer and putting the slides on that, but I found that forced dehydration didn't give me very good results. I assume it didn't give the molecules of the different component chemicals enough time to find each other.
Mike
Michael Reese Much FRMS EMS Bethlehem, Pennsylvania, USA
